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Purpose: The purpose of this research is to identify stress, depression and sleeping of mothers with children who have received the special education in the elementary, middle and high school and to find out the relationship among stress, depression and sleeping. It will be provided as the basic information for development of nursing intervention. Methods: This research was carried out from November 18th to November 27th, 2009 through questionnaire about the stress, the depression and the sleeping. The subjects of investigation were 94 mothers with children who have received the special education in elementary school, middle and high school. Results: There is correlation between the psychological and physical stress of the mothers; correlation between the stress and the depression; inverse correlation between the stress and the sleeping; and inverse correlation between the depression and the sleeping significantly in statistics (p<.001). Mother group in elementary school has mild depression and the other variables in all groups of mothers are included in normal range. Conclusion: It is necessary to do the comparative study for stress, depression and sleeping of mothers with children who have received the special education in elementary school, middle and high school and to make the research for the development of optimized nursing intervention program for reducing depression for the subjects.