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Purpose： This study was to develop and verify the effects of drug misuse and abuse preventive program for middle school students. Methods：This research was a quasi experimental study under the nonequivalent control group with pretest-post test design which tried to protect children from the detrimental effect of drugs and develop a drug abuse prevention program for middle school students. Data was collected from October 10th to 21th, 2005. Subject consisted of 145 middle school students in Kyeonggi, experimental group-72, control group-73. Dick & Carey's(1996) educational system was applied, based on documents and materials online related to drug abuse in order to develop drug abuse prevention program. It's composed of 4 parts, 45 minute each. The evaluation instrument testing for the knowledge about drugs was a criterion of referenced test items modeled by Dick & Carey. The instrument for attitudes about drugs was modeled by Kim, Soyaja. A pre-test was taken on the knowledge and attitudes to drugs. The experimental students were given four sessions of drug abuse prevention education. A post-test similar to the pre-test questionnaire was given in 1 week, 4 weeks following the last session. Collected data was analyzed by using SAS 9.1 program. Results：Followings are the summarized result of study 1. The experimental group, that attended the drug abuse prevention program will have more knowledgable about drugs than the control group (F=27.31, p<.0001). 2. The experimental group, that attended the drug abuse prevention program displayed greater negativism attitude than the control group (F=0.58, p=0.4477). Conclusion：The results conclude that drug abuse prevention programs increase the knowledge of middle school students but doesn't change their attitude toward drugs. Therefore we need to offer them more systematic education to increase their knowledge so it will also improve their attitudes as well.