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Purpose : This was aimed to investigate the effects of empirical smoking prevention program on the knowledge of the harmfulness of smoking, attitude to smoking, smoking temptation among female high school students. Methods : This study used nonequivalent control group pre and post test design. The subjects were recruited from the first and second grade at the two girls' high schools located in Ulsan city, and randomly assigned to two groups(113 in the experimental group and 117 in the control). The intervention was both the events such as nonsmoking promulgation and experiential learning programs and student-oriented educational sessions(once a week for six weeks). Data was analyzed with X2 test, t-test and ANCOVA. Results : The mean knowledge was 12.5 for pretest and 13.7 for posttest in the experimental group, and 12.7 and 13.4 in the control group, retrospectively. The mean attitude was 71.0 for pretest and 72.2 for posttest in the experimental group, and 72.3 and 72.6 in the control group, retrospectively. The mean temptation was 15.0 for pretest and 14.7 for posttest in the experimental group, and 13.9 and 14.0 in the control group, retrospectively. There's no difference in the change of the knowledge of the harmfulness of smoking, attitude to smoking, smoking temptation between experimental and control groups. Conclusion : As the possible reasons, the subjects already had sufficient knowledge on the harmfulness of smoking, the research questionnaires were too plain to get any difference, the effect of intervention was too small to show a difference in such as short-term, and finally, there were many external factors. Hence, we recommend further studies with appropriate questionnaire for longer time.