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영어

The purpose of this study was to determined the effect of endurance treadmill running exercise on expression of AMPK and MAPK in aging rat muscle. Total 32 Sprague-Dawley rats were divided into two groups by age; young group(YG; 12wk; n=16) or aging group(AG; 80wk; n=16). Each experimental group was further allocated two subgroups; Exercise(EX; n=8), Control(CON; n=8) group. All animals in exercise group performed one bout of endurance runing exercise (12m/min for 60min). The expression of phospho-AMPK by endurance exercise was significantly increased in the YG & AG. The ERK 1/2(p<.001) and p38 mitogen-activated protein kinase (MAPK)(p<.05) phosphorylation by bout endurance exercise significantly incresed in YG but decreased in AG. These results suggested that aging was significantly decreased the expression of MAP Kinase by acute endurance treadmill exercise. In conclusion the acute endurance exercise is effective in YG than AG.