원문정보
초록
영어
This study was carried out to compare the bioavailability of SR TAB (test drug, cefaclor 375 mg/Tablet) with that of Ceclor SR IAB (reference drug) and to estimate the pharmacokinetic parameters of cefaclor in healthy Korean volunteers. The bioavailability was examined on 24 healthy volunteers who received a single dose (375 mg) of each drug in the fasting state in a randomized balanced 2-way crossover design. After dosing, blood samples were collected for a period of 7 hours. Plasma concentrations of cefaclor were determined using HPLC with UV detection. The pharmacokinetic parameters were calculated with non-compartmental pharmacokinetic analysis. The ANOVA test was utilized for the statistical analysis of the , log-transformed , log-transformed , and . The ratios of geometric means of between test drug End reference drug were , respectively. The of test drug and reference drug was confidence intervals of mean difference of logarithmic transformed were log0.90-log1.04 and log0.91-log1.13, respectively. It shows that the bioavailability of test drug is equivalent with that of reference drug.