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Purpose : The purpose of this study was to explore status of activity of daily living, interpersonal relationship, depression and health-related quality of life in patients with traumatic hand injury and identify factors that influence health-related quality of life. Methods : The participants were 104 outpatients with impending hand microsurgery from D city. The data were analyed using Pearson's correlation, t-test, ANOVA, and hierarchical regression with SPSS/WIN 12.0. Results : There were statistically significant differences in HRQoL to gender, age, marital state, and level of pain. HRQoL had significant correlations with ADL, IADL, relationship change, and depression. In regression analysis, depression, marital state, A이, and level of pain explained 48% of the HRQoL. Conclusion : Findings of this study allow a comprehensive understanding of patients with traumatic hand injury. It is necessary to develop nursing intervention program for improving the health-related quality of life in patients with traumatic hand injury by considering psychological care for depression as well as physical care.