earticle

영어

The pharmacokinetics of intravenous paclitaxel (1 mg/kg) were investigated in rabbits with renal failure induced by folic acid. The area under the plasma concentration-time curve from time zero to time infinity (AUC) of paclitaxel was significantly (p<0.05) greater in rabbits with severe renal failure induced by folic acid compared to that in rabbits with in moderate renal failure induced by folic acid . The apparent volume of distribution (Vd) and the elimination rate constant of paclitaxel in rabbits with severe renal failure were significantly (p<0.05) smaller and slower respectively than those of control rabbits , but not significantly different compared with that in rabbits with moderate renal failure . total body clearance (CL) of paclitaxel in rabbits with severe renal failure was significantly (p<0.05) slower than that in control rabbits , but not significantly different compared with that in rabbits with in moderate renal failure . The terminal half-life () of paclitaxel in rabbits with severe renal failure was significantly (p<0.05) longer than that in control rabbits , but not significantly different compared to that in rabbits with moderate renal failure rabbits . The above data could be at least partly decrease in due to paclitaxel excretion in rabbits with renal failure, since of interavenous paclitaxel was excreted via kidney as unchanged forms plus its metablites.