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영어

The purpose of this study was to examine the relationship between physical fitness of people with mental retardation and insulin resistance according to β3-AR gene polymorphism. 13-17 aged people with mental retardation were selected and all subjects can communicate, have been not take antipsychotic drugs. The investigator confirmed the polymorphism of β3-AR gene via PCR technique and divided subjects into two groups(Trp/Trp, Trp/Arg). Through this study the distributions of β3-AR gene polymorphism and difference in the Physical fitness factors(6m PACER, modified curl-ups, trunk flection), body composition(height, body weight, BMI, waist measurement, hip circumference, diastolic BP, systolic BP, heart rate) and blood factosr(total cholesterol, high-density lipoprotein cholesterol, triglyceride, glucose, insulin resistance and insulin) were identified. To examine the difference between two groups according to the β3-AR gene polymorphism, independent sample t-test was carried out using SPSS/PC16.0. Study findings are as follows: There is no significant difference in such obesity factors as body fat and WHR, systolic blood pressure, diastolic blood pressure and stabilized heart rate according to the obese gene polymorphism. The 16m PACER and modified curl-ups were higher in the TT group and it was statistically significant. The trunk flexion forward, which presenting flexibility, was higher in the TT group than the TA group, but it was not statistically significant. Blood glucose and insuline resistance were higher in the TA group significantly. There was no significant difference in total cholesterol, TG, HDL and insulin. Although the β3-AR obese gene polymorphism cannot be directly regarded as the cause of obesity, its relationship with physical fitness and insuline resistance was confirmed in this study. Therefore, if the β3-AR gene polymorphism is checked in advance, obesity and secondary cardiovascular disease could be prevented. In addition, the confirmation of β3-AR obese gene polymorphism in advance seemingly has a positive effect as basic data for the working out of a health maintenance and promotion program.