원문정보
초록
영어
Recent studies have revealed that collagen peptide (CP) plays a protective role in skin by improving the activity of antioxidants and acts as an inducer of skin regeneration by positive feedback. In this study, we focused on the beneficial effect of reinforcing the CP skin barrier. To evaluate the skin barrier, hairless mice were exposed to UVB irradiation and acetone-treatment, with or without oral administration of CP. The effects on skin appearance, trans-epidermal water loss, epidermal thickness, and cytokine content were measured using bioengineering and histochemical methods. In the CP treated group, the skin had better appearance and less damage than that of the control. Furthermore, in HaCaT cells, the amount of serinepalmytoyl transferase (SPT) mRNA increased by about 1.6-fold after treatment (CP, 100 mg/L), reflecting that CP can induce SPT expression and reinforce the recovery of skin barrier function. These results suggest that CP is not only an anti-wrinkling agent but also a potent candidate as an epidermal moisturizer.
목차
서론
재료 및 방법
실험 재료
실험동물 및 사육관리
실험군 및 실험물질 투여
UV조사 및 피부 장벽 손상
In vitro 피부장벽 개선 효능평가
Cytokine 함량 평가
In vitro 피부장벽 개선 효능 평가
병리조직학적 검사
통계처리
결과 및 고찰
임상증상, 체중변화 및 섭취량 관찰
콜라겐 펩타이드 섭취에 따른 in vivo 피부 장벽 보호 효과
콜라겐 펩타이드 혼합물이 표피 항상성 유지에 미치는 영향
요약
문헌