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Purpose: The purpose of this study was to propose and to test a predictive model that could explain the workers' quality of life. Methods: Data were collected using self-report questionnaires from 901 workers in Daejeon, Korea. The questionnaires included nine measured variables (safety culture, self-efficacy, activity of occupational health provider, knowledge in occupational health, age, health promotion behavior, workplace environment, health level, and quality of life), as revised PRECEDE model has suggested. The collected data were analyzed using SPSS/ WIN 15 and AMOS 6.01 version. Results: Based on the constructed model, behavior, environment, and health were found to have significant direct effect on quality of life. Indirect factors were perceived biological, predisposing, reinforcing, and enabling. The proposed model was concise and extensive in predicting quality of life of the participants. The final modified model yielded GFI=.85, AGFI=.89, NFI=.79, and RMSEA=.11 and exhibited good fit indices. Conclusion: Findings of this study may contribute to development of effective nursing interventions for promoting quality of life in workers.