earticle

영어

Protein drugs have been widely used in various human diseases which were cancer, diabet, immune etc. However protein drugs have some problem to use therapeutic drugs (short half life, high cost). Thus several delivery technologies have been reported, microsphere, nanoparticle, ionic complex etc. Among the technologies, Poly ionic complex (PIC) has been used in protein drug delivery via charge-charge interaction. The advantage of PIC is easily prepared, but disadvantage of PIC is easily decomposition in human body condition(high concentration of salt). Several different types of PIC has been introduced to overcome this problem, which was conjugated-hydrophobic(1) and crosslinkmoiety(2). In this study, we developed novel PIC system that was conjugated thermosensitive moiety in biodegradable charged polysaccharide. And the property of thermos-ensitive-PIC was confirmed by UV-spectrophotometer, Zetasizer, and fluorescence. Thermo-sensitive PIC is successfully overcome the problem of earlier PIC system. Thus this system would be a very useful strategy for a therapeutic protein delivery.