원문정보
초록
영어
Fucoidans are sulphated polysaccharides having L-fucose as major constituent. For the past decade fucoidans isolated from various species have been extensively studied due to their numerous biological activities, including antitumor and immunomodulatory, antivirus, anticoagulant and antithrombotic, anti-inflammatory, antioxidant and and many more. However, the effect of different sizes of fucoidan on melanin synthesis has not been elucidated yet. Therefore, the aim of the present study is to identify the skin whitening effect of the fucoidans in respect to molecular weights. To confirm the depigmenting effect of the native and the acid hydrolyzed fuicoidan fractions, from Fucus vesiculosus were subjected to B16F10 melanoma and melan-a melanocyte cell line. The Cell viability (MTT) and melanin production were evaluated to elucidate the effect of fucoidan on depigmentation. The results showed that the crude fucoidan isolated from Fucus vesiculosus exhibited the melanin inhibition effect without cell toxicity up to the concentration 100 ug/ml in both cells. The purification of the hydrolyzed fractions required prior to establish the size effect of fucoidan on depigmentation. We anticipate the use of the fucoidan in different Cosmeceutical as depigmenting agent.