원문정보
초록
영어
Vitiligo is an acquired disorder of pigmentation in which depigmentation of skin and hairs occur due to the loss of functional melanocytes from the epidermis. It is known that the existence of inactive melanoblasts in the hair root follicles provides a melanocyte source for repigmentation in vitiligo. Migration of these melanocyte precursors from the outer root sheath of hair follicles into clinically depigmented epidermis is crucial for repigmentation in vitiligo therapy. Although the current natural compounds may induce varying degrees of repigmentation in vitiligo lesions, treatment challenges persist, as either not all patients respond to available therapies, and the treatment duration is too long or sometimes a plateau effect is seen with the treatment becoming less effective after an initial response. To evaluate the potential of herbal candidates in treatment of vitiligo, the effect of methanol extracts of Longanae Arillus (MELA) on differentiation, proliferation and migration in melanoblast cell was done. The results showed that, MELA could induce the differentiation and migration in melanoblast cell. From proliferation assay, MELA did not exhibit the cell toxicity to the melanoblast cell. The findings of the present study may be important in developing safer strategies for vitiligo treatment.