earticle

영어

Today Mongolia is one of the countries which officially leads its system of herbal medicine. According to their own culture and beliefs, Mongolian has developed their system of medicine, and become famous. As Chrysanthemum zawadskii, Mentha arvensis, and Lophantus chinensis are used for typical medicinal plant, this study was aimed to exploit extracts of those plants for developing functional cosmetic applications. Each sample was prepared by 0.0005%, 0.001%, and 0.002% of ethanol extraction respectively. The effect of extracts on expression of skin differentiation m arkers such as filaggrin and involucrin was measured by RT-PCR with HaCaT keratinocytes. This study showed that those differentiation markers were expressed in a dose dependent manner comparing with Ca2+ as a positive control. In addition, to determine the effect of mongolian medicinal plants on the inflammation, the pro-inflammatory cytokine, TNF-α expression in HaCaT keratinocyte will be examined by ELISA. Therefore, Mongolian medicinal plant; Chrysanthemum zawadskii, Mentha arvensis, and Lophantus chinensis extracts have affirmative effects on skin differentiation.