earticle

영어

The objective of this research was to investigate the whitening, anti-wrinkle, and anti-inflammatory effect of Jeju water containing vanadium component. In this study, Jeju water was divided into three groups (S1, S2, S3) according to its vanadium contents, i.e., the concentration of V for S1, S2, S3 were 8.0, 24.0, and 26.0 μg/l, respectively. Mushroom tyrosinase inhibition activity and anti-melanogenesis activity against melanoma cell were examined to explore Jeju water's whitening effects. In this test, Jeju water (S1, S2, S3) exhibited 6~8% inhibition activities on tyrosinase and 5~10% reduction of melanin contents in B16F10 melanoma cells. For the study of Anti-wrinkle effects, only S2 showed 5% inhibition on elastase acitivity. Jeju water (S1, S2, S3) showed 10~20% reduction on the lipopolysaccharide-induced secretion of nitric oxide in RAW264.7 cells, indicating its anti-inflammatory effects. In order to determine whether Jeju water could be safely applied to human skin, its cytotoxic effects were determined by colorimetric MTT assays in human dermal fibroblast. In this test, Jeju water did not show any cytotoxicity. All of these findings demonstrate that Jeju water containing vanadium component has beneficial effects which lead to improve human skin health.