earticle

논문검색

포스터 발표 : 바이오센서 및 바이오칩

Bioelectronic N ose w ith High S ensitivity and Selectivity using Chemically Functionalized Carbon Nanotubes Combined with Human Olfactory Receptor

원문정보

Sang Hun LEE, Hyejun JIN, Hyun Seok SONG, Eun Hae OH, Seunghun HONG, Tai Hyun PARK

한국생물공학회 한국생물공학회 학술대회 2011년도 한국생물공학회 춘계학술발표대회 2011.04 pp.261-261
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Single-walled carbon nanotubes (swCNTs) hold great promise for use as molecular wires because they exhibit high electrical conductivity and chemical stability. However, constructing swCNT-based transducer devices requires controlled strategies for assembling biomolecules on swCNTs. In this study, we developed a chemically modified swCNT for reliable attachment of the human olfactory receptor (hOR) onto the CNTs and investigated their use in the fabrication of a highly sensitive and selective bioelectronic nose. For the bioelectronic nose, the swCNT-field effect transistor platform was composed of polyethylene glycol-coated regions to prevent non-specific absorption and chemically modified swCNTs regions containing hOR, which can bind to the specific odorant. This approach allowed us to create well-defined micron-scale patterns of hOR on the swCNTs. Our bioelectronic nose displayed ultrahigh sensitivity down to concentrations as low as 1 fM. In addition, the approach described here may provide an alternative route for multiplexed detection of diverse odorants and to improve the sensitivity of sensor devices.

키워드

저자정보

  • Sang Hun LEE School of Chemical and Biological Engineering, Institute of Bioengineering, Seoul National University, Seoul, 151-742 Korea.
  • Hyejun JIN Department of Physics and Astronomy, Seoul National University, Seoul, 151-742 Korea.
  • Hyun Seok SONG School of Chemical and Biological Engineering, Institute of Bioengineering, Seoul National University, Seoul, 151-742 Korea.
  • Eun Hae OH School of Chemical and Biological Engineering, Institute of Bioengineering, Seoul National University, Seoul, 151-742 Korea.
  • Seunghun HONG Department of Physics and Astronomy, Seoul National University, Seoul, 151-742 Korea.
  • Tai Hyun PARK School of Chemical and Biological Engineering, Institute of Bioengineering, Seoul National University, Seoul, 151-742 Korea.

참고문헌

자료제공 : 네이버학술정보

    함께 이용한 논문

      ※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.

      0개의 논문이 장바구니에 담겼습니다.