원문정보
초록
영어
The development of rapid and accurate bioassay methods for pathogenic bacteria detection is of great significance in all areas related to health and safety such as clinic, food industry, environment, and defense. As surface-enhanced Raman scattering (SERS) is a convenient and sensitive method that can detect the analytes even on a single molecule level using a simple nanostructure, it has been employing as an attractive strategy for sensitive DNA sensing. Here, we developed a SERS-based Au particle-on-wire system for multiplex identification of pathogenic bacteria1. The Au NW-on-wire exhibits superb reproducibility, excellent sensitivity, and good time stability. A pattern formed by multiplex Au NW sensors provides positional address and identification for each sensor. By using this system, reference strains and clinical isolates were successfully identified, predicting practical values of this sensor in a variety of biosensing application where DNA binding involved. [This research was supported by World Class University Program (R32- 2008-000-10142-0) through the Korea Science and Engineering Foundation funded by the Ministry of Education, Science and Technology]