원문정보
초록
영어
Exess ethanol intake is usually toxic in health. Chronic ethanol consumption causes oxidative damage in liver. Acer tegmentosum MAX. good for a liver has been known since ancient times in Korea and China. Ethanol-induced oxidative stress is related to the metabolism of ethanol. The major part of the ethanol is metabolized by alcohol dehydrogenase in liver. Alcohol dehydrogenase to form acetaldehyde results in the formation of free radicals. Cytochrome P450 2E1 (CYP2E1) participates to the ethanol decomposition. Excess ethanol intake affects more microsomal enzyme CYP2E1 activity than ADH resulting in causing oxidant stress. CYP2E1 has been to be a major contributor to ethanol-induced oxidant stress. Thereby, decrease of SOD, CAT, GSH. In this study, we investigated in vitro and in vivo the inhibition of ethanol-induced liver injury by Acer tegmentosum MAX. extract. In vitro studies with ROS scavenging, decreased of CYP2E1, and increased of SOD, CAT, GSH showed that verification antioxidant activity. In vivo studies, SD Rats were treated by ethanol administration. SD Rats were injected with or without ethanol (35% ethanol, 10ml/kg per day) and Acer tegmentosum MAX. extract (120mg/kg per day) continuously for 5 week. In consequence, Acer tegmentosum MAX. extract was recognized to inhibit the liver maker emzymes (AST, ALT, GGT) and increased of SOD, CAT, GSH.