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Traditionally, mushrooms are widely used as nutritional supplements and encouraged as to be beneficial for health. Inonotus Obliquus is known to not only anti-autoimmune diseases effect but also anti-oxdative stress effect. Damage induced by oxidative stress is associated with intracellular ROS. Reactive oxygen species (ROS) are known to prime mediators of cell damage by oxidative stress. Excess production of intracellular ROS brings about on cellular tissues oxidation. Oxidation of cellular tissues leads to diseases such as aging, arteriosclerosis, inflammation, rheumarthritis and diabetes. From among these diseases, diabetes was occurred by loss of pancreatic function (destruction of pancreatic beta-cells). In this study, we investigated cytoprotect and anti-oxidative effect on mouse insulin-producing pancreatic beta-cells (MIN6N) by hot water extracts from Inonotus Obliquus.