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포스터 발표 : 세포치료 및 조직공학

Cartilage Regeneration by Microfracture and BMP-2 Delivery

초록

영어

Microfracture of cartilage induces migration of bone marrow-derived mesenchymal stem cells (BMMSCs). However, this treatment often results in fibrocartilage regeneration. Bone morphogenetic protein (BMP)-2 induce the differentiation of BMMSCs into chondrocytes, which can be used for hyaline cartilage regeneration. We tested the hypothesis that long-term delivery of BMP-2 to cartilage defects subjected to microfracture results in regeneration of high quality hyaline-like cartilage. Heparin-conjugated fibrin (HCF) and normal fibrin were used as carriers for the long and short-term delivery of BMP-2, respectively. Rabbit articular cartilage defects were treated with microfracture combined with one of the following: no treatment, fibrin, short-term delivery of BMP-2, HCF or long-term delivery of BMP-2. Eight weeks after treatment, histological analysis and biochemical assay revealed that the long-term delivery of BMP-2 group had the highest GAG content and expression level of collagen type II. Taken together, the long-term delivery of BMP-2 to cartilage defects subjected to microfracture resulted in regeneration of hyaline-like cartilage.

저자정보

  • Hyeon-Ki JANG Interdisciplinary program of Bioengineering, Seoul National University, Seoul.
  • Hee Seok YANG Department of Bioengineering, Hanyang University, Seoul, 133-791.
  • Wan-Geun LA School of Chemical and Biological Engineering, Seoul National University, Seoul.
  • Suk Ho BHANG School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744.
  • Hak-Jun KIM Department of Orthopaedic Surgery, Ansan Hospital, College of Medicine, Korea University, Ansan.
  • Jung-Ho PARK Department of Orthopaedic Surgery, Ansan Hospital, College of Medicine, Korea University, Ansan, 425-020.
  • Byung-Soo KIM Interdisciplinary Program of Bioengineering, Seoul National University, Seoul, 151-744.

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