earticle

영어

Kinetic simulation model of metabolites behavior is needed for an optimal design of bioreactor and developing of operation strategy. However, the estimation of dynamic behavior of metabolites in Acetone-Butanol-Ethanol(ABE) fermentation by clostridum is difficult, because of the complexity of metabolic pathway due to two distinct characteristic phases(acidogenesis, solventogenesis), substrate inhibition, and product inhibition. In this study, we developed the kinetic simulation model of ABE production which is based on the metabolic pathway by butyrate kinase knock-out clostridium. We estimated the kinetic parameter in this model using the experimental data.