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영어

‘imchi’is a fermented food in Korea. Distinctive flavors and colors in every province of Korea can vary the nutrients as well as amino acids, minerals, and vitamins lacking in the hulled rice particularly. However, functional nutritional ingredients abundant in Kimch are not identified. General Kimchi and mushroom Kimchi with different 7 species mushroom extracts were investigated in this study. Kimchi extracts by syringe (25 mm, 45 micron) filtration were examined for mouse spleen, lymphocytes cells, cell proliferation assay (MTT assay), cell death analysis (apoptosis analysis), and gene expression analysis (Real Time PCR). It is reported that mushroom Kimchi affected the proliferation of mouse spleen cells than that of conventional Kimchi. Along with that, our findings showed that mushroom Kimchi inhibited the proliferation of cervical cancer cell (Caski) and breast cancer cell (MCF7) through the MTT assay. For analysis of cell death caused by the mushrooms Kimchi, early apoptosis cells increased. Anticancer effect by mushroom Kimchi extract resulted in the expression of genes identified p53, caspase 3,8,9, compared to control experiments. Acknowledgement This research was financially supported by the Ministry of Education, Science Technology (MEST) and Korea Industrial Technology Foundation (KOTEF) through the Human Resource Training Project for Regional Innovation (2010).