earticle

영어

Hydroxyapatite (HA) has been extensively used as an implant material because of its similarity with human bone composition and its ability to form a strong bond to the human hard tissue. Silver (Ag) and Ag-containing compounds are highly antimicrobial activity to 16 kinds of bacteria. The antibiotic effect of Ag draws much attention because of the low toxicity of the active Ag ion to human cells. We studied the antimicrobial effects of Ag coated HA nanofibers. Dimethylformamide (DMF) solution having polyacrylonitrile (PAN) and sonicated HA was used for the preparation of nanofibers by electrospinning. Ag coated nanofibers were prepared by two ways. The mixture of Ag, PAN, and HA was electrospinned or nanofibers were soaked into Ag solution. The antimicrobial effects of nanofibers against E coli, K pneumoniae (Gram-negative) and S aureus (Gram-positive) were investigated by paper disc or shaking flask method. Nanofibers containing HA and Ag coated nanofibers exhibited high antibacterial activity against gram-negative and gram-positive both. Our results indicated that HA containing fibers might be a promising antimicrobial biomaterial.