earticle

영어

This study is aimed to evaluate the protective effect of Cordycepin-increased Cordyceps militaris(CM) strain on the triglyceride metabolism in orotic acid (OA)-fed rats was investigated. Male Sprague-Dawley rats were randomly divided into six groups (n=6) based on five dietary categories: Normal, OA control, OA plus Paecilomyces japonica (PJ)(3%,w/w), OA plus Cordyceps militaris (CM)(3%,w/w), OA plus Cordycepin- increased CM(3%,w/w). The activities of liver marker enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and the levels of lipid peroxidation were increased when OA was treated but these parameters were significantly decreased by Cordycepin-increased CM. OA treatment exhibited decrease in serum concentrations of triglyceride, total cholesterol, HDL-cholesterol and free fatty acids and these were also decreased by Cordycepin-increased CM. The current study observed significant elevations of the thiobarbituric acid-reactive substances (TBARS) levels. However, among the OA, Cordycepin-increased CM was significantly lowered in the TBARS levels of hepatic homogenate. OA resulted in a significant decrease in the levels of plasma and hepatic glutathione, but these reductions were significantly increased by Cordycepin-increased CM. Accordingly, Cordycepin-increased CM bean ideal can did ate for the hepatoprotective effect in animal model.