원문정보
초록
영어
The emergence of antibiotic-resistant pathogens has rekindled interest toward the discovery of new antibiotics. Semi-synthetic or biosynthetic approach using microbe as a biocatalyst can be an efficient tool for the targeted modification of existing antibiotic chemical scaffolds to create the next generation of antibiotics as well as previously uncharacterized therapeutic agents. An attempt was made to expand the applicability of the unique bio-hydrogenation activity of Streptomyces venezuelae toward other unsaturated macrolide antibiotics (natural oligomycin A and semisynthetic tilmicosin) that possess the above mentioned identical catalytic scaffold, and the structure and antibiotic potential of two previously uncharacterized macrolides, 2,3-dihydro-oligomycin A and 10,11-dihydro-tilmicosin, isolated from a S. venezuelae culture supplemented with oligomycin A and tilmicosin, respectively, were evaluated.