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논문검색

학생구두발표 (영문 I) : 좌장 : 김 소 미(제주대), 최 신 식(명지대)

Transcriptoin factor (MITF) and DNA (E-box) Binding Analysis for Pigment Control in Skin by Surface Plasmon Resonance

원문정보

Man-Ki SON, Hyang-Bok LEE, Dung HOANG NGUYEN, Eun-Ki KIM

한국생물공학회 한국생물공학회 학술대회 2011년도 한국생물공학회 춘계학술발표대회 2011.04 pp.139-139
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

MITF (microphthalmia-associated transcription factor), a bHLH (basic helix-loop-helix) transcription factor with a leucine zipper, is a key regulatory protein for the pigmentation process in melanocytes. Binding of MITF to E-box caused transcription of several pigmenting genes, including the tyrosinase gene. The purpose of this study is to analyze the interaction of MITF and its DNA binding site (E-box, CATGTG) by surface plasmon resonance. Label free DNA-protein interaction assay, SPR (surface plasmon resonance) was used to analyze their interactions on the gold surface. It is expected that SPR can be a useful method to study of MITF and E-box interactions. We are looking forward to applying this study as a screening tool for depigmenting agents in the cosmetic industry.

키워드

저자정보

  • Man-Ki SON Dept. of Biological Engineering, Inha University, Incheon.
  • Hyang-Bok LEE Dept. of Biological Engineering, Inha University, Incheon.
  • Dung HOANG NGUYEN Dept. of Biological Engineering, Inha University, Incheon.
  • Eun-Ki KIM Dept. of Biological Engineering, Inha University, Incheon.

참고문헌

자료제공 : 네이버학술정보

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