earticle

영어

Corydalis heterocarpa, a kind of salt-tolerant plant, has been employed as folk medicine to cure travail and spasm, and some studies have reported the antioxidant and anti-inflammatory activities of components isolated from Corydalis heterocarpa. However, whether compound isolated from this plant attenuates the UVB-induced cell damage in skin still remains largely unknown. Solar ultraviolet (UV) radiation, particularly the UVB (290-320 nm) radiation causes various harmful biological effects including sunburn, melanoma and photoaging. This stud focused on the investigation of anti-photodamage effects of compound isolated from corydalis heterocarpa on UVB induced human keratinocyte (HaCaT) cells. The presence of compound in UVB-exposed keratinocytes suppressed the reactive oxygen species (ROS) generation and DNA damage. In addition, the compound down regulated the increased MMP-2, MMP-9 and up regulated the reduced TIMP-1, TIMP-2 protein and gene expressions due to UVB exposure. Furthermore, the under lying signaling mechanisms of UVB protective effects of compound was elucidated through ASK1-MAPK-responsive signaling pathways.