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논문검색

Bio-inspired Biotechnology Symposium : 공동개최 : KAIST 분자생물공정융합기술연구단 : 좌장 : 박 찬 범(KAIST)

Biosynthesis of Ultra High Molecular Weight Spider Silk Protein

원문정보

Do Kyun Na., Sang Yup LEE, Xiao-Xia Xia, Zhi-Gang Qian, Young Hwan Park

한국생물공학회 한국생물공학회 학술대회 2011년도 한국생물공학회 춘계학술발표대회 2011.04 pp.117-117
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Spider silk fiber spun from spider is extremely strong and as strong as Kevlar. However, this great material property could not be realized so far by using the made recombinant spider silk proteins. In this lecture, I will report designing of synthetic gene modules, systems metabolic engineering of E. coli network to increase the required metabolic fluxes, and cellular engineering to cope with increased tRNA pool. This allowed production of ultra high molecular weight spider silk protein in E. coli, which gave Kevlar strength silk fiber when spun. [This work was supported by the Korean Systems Biology Research Project (20100002164) of the Ministry of Education, Science and Technology (MEST) through the National Research Foundation of Korea. Further support by the World Class University Program (R32-2008-000- 10142-0) through the National Research Foundation of Korea funded by the MEST is appreciated.]

키워드

저자정보

  • Do Kyun Na. Department of Chemical and Biomolecular Engineering (BK21program), Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST.
  • Sang Yup LEE Department of Chemical and Biomolecular Engineering (BK21program), Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST.
  • Xiao-Xia Xia Department of Chemical and Biomolecular Engineering (BK21program), Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST.
  • Zhi-Gang Qian Department of Chemical and Biomolecular Engineering (BK21program), Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST.
  • Young Hwan Park Department of Biosystems and Biomaterials Science and Engineering, Seoul National University, Seoul 151-921

참고문헌

자료제공 : 네이버학술정보

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