earticle

영어

The central strategy in tissue engineering involves a biomaterial scaffold as a delivery carrier of cells and a depot to deliver bioactive molecules. The ability of scaffolds to control cellular response to direct particular repair and regeneration processes is essential to obtain functional tissue engineering constructs. Therefore, many efforts have been made to understand local interactions of cells with their extracellular matrix (ECM) microenvironment and exploit these interactions for designing an ideal scaffold mimicking the chemical, physiological, and structural features of native ECM. ECM is composed of a number of biomacromolecules including proteins, glycosaminoglycans, and proteoglycans, which are assembled together to form complex 3-dimensional network. Cells are bound to these ECM components, which in many cases, is implicated in critical cell fate process such as adhesion, proliferation, differentiation, and survival. In this presentation, our approaches to develop cell-interactive scaffolds for modulation of cell function by providing several exemplary works of engineering bone, muscle, ischemic, and neural tissue.