earticle

영어

One of the key factors to influence the specific productivity of whole-cell biocatalysts for the production of fine chemicals (e.g., alcohols, carboxylic acids) is efficiency of biosynthetic pathway to the target molecules from the reaction substrates as well as of background metabolic pathways to provide cofactors (e.g., NAD(P)H, ATP) required for the production of target compounds1-3. This presentation will focus on impact of the background metabolisms on oxygenation of cyclohexanone and styrene by recombinant Escherichia coli to provide the critical factors in metabolic engineering and optimization of whole-cell biocatalysts in biorefinery.