earticle

영어

Protective effects of Gamdutang Extract(GDE) on the toxicity of Cisplatin and Carboplatin in rats were examined. Experimental groups were treated with 5mg/kg/day Cisplatin and Carboplatin by intraperitoneal injection and GDE 250mg/kg, 500mg/kg and 1000mg/kg by oral administration for 5 days. The exposure of Cisplatin and Carboplatin showed the toxicity at all experimental assay as gain of body weight, the ratio of organ weight to body weight and the serum parameter. This toxicity was restored by GDE administration.