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논문검색

Vancomycin 초기 투여 용량 개선 방안

원문정보

Development of Vancomycin Initial Dosage Guidelines to Achieve New Target Ranges

유재영, 김정현, 인용원, 김은영, 손기호

피인용수 : 0(자료제공 : 네이버학술정보)

초록

영어

In 2009, American Journal of Health-System Pharmacy (AJHP) recommended that targeting vancomycin trough concentrations of 10 mg/L or more because of therapeutic failure and potential risk of developing vancomycin resistance. Therefore, new dosage guidelines that could achieve to these higher target were needed. The aims of this study were to develop dosage guidelines targeting new vancomycin trough concentration and to evaluate the performance of these new guidelines. All data analysis were performed using NONMEM®. Population pharmacokinetic model was first developed from vancomycin dosage and concentration data collected retrospectively during routine therapeutic drug monitoring in 441 patients, then new vancomycin dosage guidelines were developed by using the model to predict vancomycin trough and peak concentrations in a simulated dataset. The estimates, such as, vancomycin concentration trough level, time to achieve target level, mean error were performed to evaluate and compare difference between conventional dosage and new dosage guidelines. The proposed dosage guidelines were predicted to achieve 43.5% of vancomycin trough level within 10~20 mg/L, which is significantly higher than current guidelines (26.3%). Time to achieve target trough level was 19.4 hours in new guidelines comparing to 93.1 hours in the conventional dosage. Thus, new vancomycin dosage guidelines have been developed to achieve new target trough concentrations earlier and more consistently than conventional guidelines.

목차

Abstract
 연구방법
  연구 대상 및 자료의 수집
  집단 약동학 모델링
  Vancomycin 용량용법 가이드라인 설정
  새 가이드라인의 효용성 평가
  통계분석
 연구결과
  연구대상 환자군의 특성
  집단 약동학 모델링
  Vancomycin 투여 가이드라인 설정
  새 가이드라인의 효용성 평가
 고찰
 결론
 참고문헌

저자정보

  • 유재영 Jae-Young Yoo. 삼성서울병원 약제부
  • 김정현 Jung-Hyun Kim. 삼성서울병원 약제부
  • 인용원 Yong-Won Lee. 삼성서울병원 약제부
  • 김은영 충남대학교 약학대학
  • 손기호 Kie-Ho Sohn. 삼성서울병원 약제부

참고문헌

자료제공 : 네이버학술정보

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