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Modeling of Ammonium Lactate Recovery from Fermentation Broth by Nanofiltration

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In this study, Nanofiltration (NF) with TFC-SR2 membrane was used to recover ammonium lactate from model solution. A modeling method based on multistage version of NF process has been proposed to represent this process. Prior to process modeling, the structural and electrostatic parameters of the membrane used were determined by using the Spigler-Kedem (SK) model and steric hindrance pore model.
For the estimation of model parameters associated with the NF process under consideration, experiments at different concentrations and operating pressures were performed. The lactate rejection at the given pressure was empirically represented as a function of its concentration by nonlinear curve fitting. For the determination of solution flux, the reflection coefficient and effective volume charge density were calculated by using the SK model together with the Teorell–Meyer–Sievers model. Time profiles of lactate concentration in the permeate predicted by the proposed model were in a good agreement with the experimental data. The utilization of the model for simulation study will be addressed, to select optimal process options and to optimize process conditions with consideration of the lactate yield and the accumulation of major impurities.

저자정보

  • Jae Hyung KIM Biosystem Engineering Laboratory, Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu Daejeon.
  • Yong Keun CHANG Biosystem Engineering Laboratory, Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu Daejeon.

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