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논문검색

바이오의약 및 약물전달

Anti-Cell Adhesion Capacity of Siegesbeckiae Herba and Corni Fructus for Anti-Obesity Purpose

원문정보

Jong Deog KIM, Gyu Seung YANG, Jin Hyuk SHIN, Gu Yong CHA, Hui Jin KIM, Jong Suk KWAK, Jae Ho HWANG, Kyeong Ho HAN, Hyo Jin SEO, Suk Jung OH

한국생물공학회 한국생물공학회 학술대회 2010 추계학술대회 및 국제심포지움 2010.10 pp.270-270
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Cell adhesion is essential for tissue and organ formation, and alive of cell. Cell adhesion is also stimulated by VEGF. Cell adhesion is important factor for cancer and obesity. These two kinds of natural products of Siegesbeckiae Herba and Corni Fructus showed novel anti-cell adhesion. In the anti-cell adhesion experiment, U937 cells to IL-1β-chemical stimulated HUVECs were completely suppressed by 28%, 61%, 70% and 158% at different concentration of S. herba and C. fructus inhibited U937 cell adhesion to 12%, 57%, 115% and 132%, respectively. Also, U937 cell adhesion was inhibited by 372%, 613%, 633% and 720% at different concentration of S. herba and was inhibited by 379%, 504%, 567% and 664% at different concentration of C. fructus when interacting with PMA-chemical stimulated U937 cells to HUVECs. Finally, U937 cell adhesion was inhibited by 93%, 95%, 375% and 436% at different concentration of S. herba and was inhibited by 50%, 112%, 231% and 297% when interacting with chemical stimulated U937 to IL-1B-chemical stimulated HUVECs. These results suggest that S. herba and C. fructus extracts could be anti-angiogenesis substances for anti-obesity.

키워드

저자정보

  • Jong Deog KIM Department of Biotechnology & Research center on Anti-Obesity and Health Care, Chonnam National University, 550-749.
  • Gyu Seung YANG Department of Biotechnology, Chonnam National University, 550-749.
  • Jin Hyuk SHIN Department of Biotechnology, Chonnam National University, 550-749.
  • Gu Yong CHA Dept. of Culture Biotechnology, Chonnam National University,550-749.
  • Hui Jin KIM Dept. of Culture Biotechnology, Chonnam National University,550-749.
  • Jong Suk KWAK Department of Biotechnology, Chonnam National University, 550-749.
  • Jae Ho HWANG Dept. of Culture Biotechnology, Chonnam National University,550-749.
  • Kyeong Ho HAN Dept. of Culture Biotechnology, Chonnam National University,550-749.
  • Hyo Jin SEO Department of Biotechnology, Chonnam National University,550-749.
  • Suk Jung OH ECOBIO INC, TBI center, 500-757.

참고문헌

자료제공 : 네이버학술정보

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