earticle

영어

Eicosapentaenoic acid(EPA) in one of omega-3 fatty acids in unsaturated fatty acids and plays a pivotal role in protection against oxidative damage-related diseases due to anti-inflammatory effects.In this study, anti-inflammatory effects of EPA loaded nano-particles(ENP) on lipopolysaccharide(LPS)-induced murine macrophage cells (RAW264.7) were investigated. The nanoparticles released EPA which was able to inhibit the production of nitric oxide (NO) by suppressing the expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW 264.7 macrophage cells. NO production and iNOS expression was significantly decreased in dose-dependent manner when cells were treated with various concentrations of ENP.