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화장품

Transcription factor (MITF) and DNA (E-box) Binding Analysis by Surface Plasmon Resonance for Pigment Control in Skin

원문정보

Man-Ki SON, Hyang-Bok LEE, Dung Hoang NGUYEN, SunA YOON, Jimin UM, Eun-Ki KIM

한국생물공학회 한국생물공학회 학술대회 2010 추계학술대회 및 국제심포지움 2010.10 pp.261-261
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

MITF (microphthalmia-associated transcription factor), a bHLH (basic helix-loop-helix) transcription factor with a leucine zipper, is a key regulatory protein for the pigmentation process in melanocytes.
Binding of MITF to E-box caused transcription of several pigmenting genes including the tyrosinase gene. The purpose of this study is to analyze the interaction of MITF and its DNA binding site (E-box, CATGTG) by surface plasmon resonance. Label free DNA-protein interaction assay, SPR (surface plasmon resonance) was used to analyze their interactions on the gold surface. It is expected that SPR can be a useful method to study of MITF and E-box interactions. And we hope to apply this study as a screening tool for depigmenting agents in the cosmetic industry.

키워드

저자정보

  • Man-Ki SON Dept. of Biological Engineering, Inha University, Incheon, 402-751.
  • Hyang-Bok LEE Dept. of Biological Engineering, Inha University, Incheon, 402-751.
  • Dung Hoang NGUYEN Dept. of Biological Engineering, Inha University, Incheon, 402-751.
  • SunA YOON Dept. of Biological Engineering, Inha University, Incheon, 402-751.
  • Jimin UM Dept. of Biological Engineering, Inha University, Incheon, 402-751.
  • Eun-Ki KIM Dept. of Biological Engineering, Inha University, Incheon, 402-751.

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자료제공 : 네이버학술정보

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