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영어

The inhibitory effect on melanogenesis was studied to develop a new natural whitening agent for cosmetics. Various extracts of Clematis apiifolia DC. were tested for the screening. Free radical scavenging activities of extracts (DPPH) IC50 were analyzed for the antioxidant capability of extracts. Mushroom tyrosinase inhibition activities were tested for the enzymatic melanogenesis inhibition. Further inhibitory effect on melanogenesis was tested with B16 melanoma cells by measuring the content of melanin synthesized. Clematis apiifolia DC. was resulted as a good candidate of a new natural whitening agent for cosmetics.