earticle

영어

Alzheimer’s disease (AD) is the most common neurodegenerative dementia. Although the number of AD patients is currently dramatically increasing, tool for definitive diagnosis is the only postmortem examination of brain tissue. Therefore, the development of new biomarkers is necessary for early detection of AD before onset of clinical symptoms.
In this study, plasma proteomes of 2 mon (n=13, asymptomatic) and 4 mon (n=7, symptomatic) tau transgenic mice (pNSE/htau23) were compared to control group (n=8) by two-dimensional gel electrophoresis (2-DE). As a result, 18 proteins (200% up-regulated and 50% downregulated compared to control, respectively) were identified by LCMS/MS. Among these proteins, 3 meaningful proteins, I (p<0.001), Ⅱ (p<0.01), and Ⅲ (no significance), and their tendency of change were confirmed by Western blotting. In the conclusion, this finding suggests that the 3 proteins related to metabolism and energy deficiency and to apoptosis induction in AD mechanism have a potentiality to be diagnostic tool for early detection of AD.