earticle

영어

Collagen and hyaluronic acid (HA) are the most widely used for implantable matrices, because of its biocompatibility and bioresorbability.
In this study, we investigated the possibility of HA derivative particlescollagen (HADP-Col) gel as an injectable scaffold in cartilage tissue engineering. We extracted collagen from human umbilical cord matrix and HA were cross-liked by 1,4-butane-diol diglycidyl ether. Then they were mixed homogeneously with umbilical cord-mesenchymal stem cells to become a flowable gel. Consequently, the viability and growth of the cells was promoted in vitro. After chondrogenic induction, RT-PCR and histological analysis showed that the stem cells were successfully differentiated into chondrocytes. With the above results, the injectable HADP-Col gel can be used in the field of stem cell therapy.