earticle

영어

The interface between neural electrodes and neural tissue plays an important role in chronic in vivo recording of neural signal. However, when these devices are implanted in to nerve tissue for recording of neural signal, they lose electrical connectivity due to inflammatory reaction, nonspecific protein adsorption and cell adhesion. In this study, to enhance the short-term and long-term biocompatibility of neural electrode, residual solvent extraction, anti-inflammatory drug loading and surface immobilization processes were carried out. Residual solvent in the neural electrode was reduced by solvent extraction and ultra-sonication processes. To reduce the post-inflammatory reaction, an anti-inflammatory drug embedded in a polyimide (PI) film. To modify the surface of the PI film for reducing protein absorption and cell adhesion, oligo (ethylene glycol) methacrylate (OEGMA) was grafted on the surface of PI films by surface-initiated atom transfer radical polymerization (SI-ATRP). The biocompatibility of the PI film was analyzed using the cytotoxicity, RT-PCR, and H&E staining. Neural electrode that is contained drug show better short term biocompatible characteristics over control neural electrode. These solvent reduction, drug containing, and surface immobilized PI film can be used to increase the biocompatibility of neural electrode.