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식품 및 바이오신소재

Inhibitory Effects of Pine gnarl Water Extracts on Atopic Disease

원문정보

Chung-Jo LEE, Eu-Jin SONG, Ji-Hee KWAK, Koth-Bong-Woo-Ri KIM, Ji-Yeon JUNG, Min-Ji KIM, Moon-Kyung CHOI, Dong-Hyun KIM, Chan SUNWOO, Dong-Hyun AHN, Tae-Wan KIM

한국생물공학회 한국생물공학회 학술대회 2010 추계학술대회 및 국제심포지움 2010.10 pp.206-206
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Many investigators have tried to look for atopic dermatitis medicine from natural resources lately because the occurrence of atopic dermatitis has been continuously increasing. Therefore, an aim of this study is to examine inhibitory effects of pine gnarl water extracts (PGWE) on atopic dermatitis. To conduct this experiment, PGWE was added to splenocytes obtained from OVA-immunized mice for an in-vitro test. In addition, an anti-atopic dermatitis test was carried out by spreading PGWE on the dorsal skin of 2,4dinitrochlorobenzene (DNCB)-induced balb/c mice. It was verified that the IFN-γ, IL-4 and total IgE secretion was suppressed when PGWE was added to splenocytes obtained from OVA-immunized mice. For anti-atopic dermatitis test, PGWE alleviated symptoms of the erythema, crust and dryness in DNCB-induced mice.
Furthermore, the IFN-γ, IL-4 and total IgE secretion of the group treated with PGWE in splenocytes and sera considerably diminished compared to the positive control. Through these results, we can conclude that PGWE can inhibit allergy and atopic dermatitis by modulating IFN-γ, IL-4 cytokine and IgE secretion.

키워드

저자정보

  • Chung-Jo LEE Dept. of Food Science and Technology, Pukyong National University, Busan 608-737.
  • Eu-Jin SONG Dept. of Food Science and Technology, Pukyong National University, Busan 608-737.
  • Ji-Hee KWAK Dept. of Food Science and Technology, Pukyong National University, Busan 608-737.
  • Koth-Bong-Woo-Ri KIM Dept. of Food Science and Technology, Pukyong National University, Busan 608-737.
  • Ji-Yeon JUNG Dept. of Food Science and Technology, Pukyong National University, Busan 608-737.
  • Min-Ji KIM Dept. of Food Science and Technology, Pukyong National University, Busan 608-737.
  • Moon-Kyung CHOI Dept. of Food Science and Technology, Pukyong National University, Busan 608-737.
  • Dong-Hyun KIM Dept. of Food Science and Technology, Pukyong National University, Busan 608-737.
  • Chan SUNWOO Dept. of Food Science and Technology, Pukyong National University, Busan 608-737.
  • Tae-Wan KIM Dept. of Food Science and Technology, Andong National University, Gyeongbuk 760-749.
  • Dong-Hyun AHN Dept. of Food Science and Technology, Pukyong National University, Busan 608-737.

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자료제공 : 네이버학술정보

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