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In this study, the effects of fucoidan on aspirin-induced ulcers in rats were evaluated: both biochemical and immunological parameters were taken into consideration. The status of stomach tissue glycogen storage and histological changes were also examined. Examination of basic biochemical parameters showed significant (p <0.01) alterations in aspartate (AST) and alanine (ALT) transaminases in ulcer-induced rats.
Also, moderate alterations (p <0.05) were observed in the levels of cholesterol and blood urea nitrogen (BUN). Analysis of serum cytokines of aspirin-induced rats showed a moderate decrease in interleukin-10 (IL-10) with considerable increase of interleukin-6 (IL-6) and interferon-γ (INF-γ) when compared with control. Administration of fucoidan showed considerable (p <0.05) protection against ulceration by inhibiting the acute alterations of AST, ALT, cytokines and stomach glycogen.
However, aggravated serum INF-γ was observed in the fucoidanpretreated group. These findings suggest that the anti-ulcer property of fucoidan might contribute in protecting the inflammatory cytokinemediated oxidative damage to gastric mucosa.