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유전자 및 대사공학

Comparative proteome analyses of solvent-producing Clostridium acetobutylicum

원문정보

Min Young KIM, Yu Sin JANG, Joungmin LEE, Sang Yup LEE, Mi Jung HAN

한국생물공학회 한국생물공학회 학술대회 2010 추계학술대회 및 국제심포지움 2010.10 pp.190-190
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Clostridium acetobutylicum is a model organism for butanol production. C. acetobutylicum M5 is a degenerate derivative of C. acetobutylicum ATCC824. Loss of solvent production in this strain can be complemented by over-expression of adhE1-ctfAB. This strain, M5 (pIMP1E1AB), produced butanol with reduced amounts of other solvents relative to the wild-type strain C. acetobutylicum ATCC824. A high butanol selectivity of 0.84 was achieved. In this study, we used a proteomics approach to examine changes in global protein expression between solventogenic C. acetobutylicum ATCC824 and degeneratenonsolventogenic C. acetobutylicum M5. In order to further understand M5 (pIMP1E1AB) strain, we also compared protein expression patterns to those in the wild type ATCC824 strain, both in acidogenic and solventogenic phases. [This work was supported by the Ministry of Knowledge Economy grant funded by the Korea government (#10030795). Further supports by the GS-Caltex and the BioFuelChem].

키워드

저자정보

  • Min Young KIM Dept. of Chemical and Biomolecular Engineering, KAIST, Daeson, 305-701.
  • Yu Sin JANG Dept. of Chemical and Biomolecular Engineering, KAIST, Daeson, 305-701.
  • Mi Jung HAN Dept. of Chemical and Biomolecular Engineering, KAIST, Daeson, 305-701, Department of Biomolecular and Chemical Engineering, Dongyang University, Korea.
  • Joungmin LEE Dept. of Chemical and Biomolecular Engineering, KAIST, Daeson, 305-701.
  • Sang Yup LEE Dept. of Chemical and Biomolecular Engineering, KAIST, Daeson, 305-701.

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자료제공 : 네이버학술정보

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