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영어

Actinobacillus pleuropneumoniae is the causal agent of swine pleuropneumoniae, a disease resulting in morbidity and mortality of pigs and accordingly economic losses within the swine industry. Toxins (Apx) produced by A. pleuropneumoniae appear to be important virulence factors of swine pleuropneumoniae. Recently, in order to effective immune responses, various peptides and proteins for binding gangliosides. The role of gangliosides in mucosal immunization has attracted attention due to the emerging interest in oral vaccination.
Ganglioside GM1 exists in abundance on the surface of the M cells of Peyer’s patch, a well-known mucosal immunity induction site. It was previously reported that peptide for GM1-specific peptides from a phage display library. The motif of Co1, expect to bind GM1 effectively. In the present study we have expression of ApxIIA toxin epitope of Actinobacillus pleuropneumoniae fused with Co1 ligand of a peptide enhancing mucosal and systemic immune response.