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natural antibiotic compound from microbial source are promising for future. Batch and fed-batch culture was carried out to enhance the antibiotics production from B.subtilis produce surfactin-like lipopeptide antibiotics. Dextrose was best carbon source for high production in batch culture. For fed-batch, optimal glucose concentration was 1.5 % around and this concentration showed best antibiotics production rate.
Cell growth was also highly enhance by glucose feeding. Ammonium was best nitrogen source for antibiotics production for this strain and it concentration was 4% around. Other salts such as magnesium, manganese, ferrous, and potassium ion was also important for growth as well as production.