원문정보
초록
영어
Biological effects of nanomaterials with a focus on toxicity should receive great attention since commercial products as well as medical tools increasingly utilize them. Especially, a fundamental understanding of nanotoxicology is highly desirable both from the material’'s stand point as well as from the biological system’'s point of view. Titanium dioxide (TiO2) is a widely used material in our life: for example, cosmetics of sun-cream to block UV radiation. However, despite its wide array of common applications, its pathogenetic role was always suggested under certain conditions. In this work, the toxicity of TiO2 nanoparicles on human skin- and lung cell was investigated using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfo phenyl)-2H-tetrazolium (MTS) assay- and confocal microscopy for live &dead of cells. The human skin- and lung-cell were purchase from from Korean Cell Line Bank. We observed that TiO2 nanoparticles impedes the cell growth using MTS, and dead cells increase depending on the concentration of TiO2 nanoparticles using confocal microscopy.
Based on the results mentioned above, we discuss the toxicity and the safety of TiO2 nanoparicles for the human cells.