earticle

영어

Today a number of nanoparticles (NPs) are applied for medical or medicinal research fields through conjugating with drugs or bio-molecules such as DNA, RNA, and peptides. There are three distinct ways to deliver NPs into animal and human bodies; injection, feeding, and trans-dermal administration. The array of microneedles with length ranging from 600μm to 1.5mm was fabricated using laser-printed PDMS (polydimethylsiloxane) mold and biodegradable polymers such as CMC (Carboxymethyl cellulose), agarose, and etc. The 50 nm fluorescence iron oxide and polystryrene NPs were successfully attached to the surface of microneedles by spraying NPs onto the inner surface of mold. When the array of microneedles was applied to the swine skin, NPs were detected in the hypodermis. Microneedle array conjugated with nanoparticles is expected to be an alternative method to deliver cosmetical or pharmaceutical materials into human skin locally without professional procedures.