earticle

영어

Here, we have developed a highly elegant and simple bioconjugation strategy in combination with genetic code engineering. We show for the first time the residue specific incorporation of hormonal precursor 3, 4‐dihydroxy‐L‐phenylalanine (L‐DOPA) can alter the functional properties of protein to conjugate into the polymers. This facile method will facilitate the synthesis of homogeneously modified protein. It yields quinone residues that are covalently conjugated to nucleophilic groups of the amino polysaccharide. This novel approach holds great promise for wide spread use to fabricate protein conjugates and development of protein microarray and synthetic biology applications.