earticle

영어

Streptomyces which is Gram‐positive, filamentous and soil dwelling bacteria produce various secondary metabolites including antibiotics, peptides and various pigments 1. In the research of Streptomyces, study of regulators related to producing antibiotics has potential to supplement the existing method like random mutagenesis and change more global metabolic flux than single enzyme in metabolic pathway.
In addition, many examples of regulators such as ActII‐ORF4 of S. coelicolor 2, StrR of S. griseus 3 and DnrI of S. peucetius 4, TylS and TylR from S. fradiae 5, WblA from S. peucetius 6 also show possibility that the results of characterizing regulators can be applied to develop more efficient industrial strain by directly up‐ and down‐regulating antibiotic biosynthetic gene clusters. To find out unknown regulators affecting primary and secondary metabolisms in Streptomyces coelicolor, we applied different omics approaches for screening of regulators and characterization of new regulators, and characterized several regulators such as NdgR and AbsC.