earticle

영어

This thesis was to prove the possibility of aroma essential as alternative medicine in curing AD and its efficacy. The experiment was executed first in relation to animal model and next to AD patients sample. The immunological factors were analysed in animal model and the degree of satisfaction and effectiveness factors were measured in AD patients. For this purpose, the oil mixture was fabricated by blending three essential oils(carrot seed, geranium, lemon : CGL) and one carrier oil(jojoba). CGL ointment was made on the atopy dermatis skin lesions-induced in NC/Nga Mice animal model by DNCB, the artificial AD stinulator. The mixture ratio of each oil was 1(carrot seed) to 1(geranium) to 1 (lemon) on the basis of drop and this mixture was blended with jojoba oil. The dilution ratio of essential oils and carrier oil was 2%. The CGL ointment was made for 8 weeks. AD patients sample was 30 and surveyed by the questionnaire with high reliability. The result of this stury can be outlined as follows: First, the CGL showed positive effect in AD skin features. Second, the thickness of epidermis/dermis was reduced and the infiltration rate of immunocytes was largely decreased compared with that of the control group. Fifth, the respondents answered relatively high degree of satisfaction after using CGL. The degree of satisfaction increases with passage of weeks reaching the highest point fourth week. The results were strongly affirmative. The CGL was effective in elevating immunological capability in animal model and the response of AD patients was affirmative. These results mean that aroma essential oil can possibly be used widely for human kind. For this, the more sophisticated further rersearches are needed

한국어

본 연구에서는 부작용의 가능성이 적어 인체에 안전한 천연오일을 이용한 아토피 개선 오일의 효능을 검증하고자 하였다. 이를 위해 기초 자료검색과 임상을 통하여 가능성이 있을 것으로 사료되는 캐롯 시드, 제라늄, 레몬, 호호바를 혼합하여 아토피 피부염 동물 모델인 Nc/Nga Mice를 통해 피부염 실험을 하고, 이 오일을 아토피 피부염 환자를 대상으로 효능 평가를 실시하였는바, 동물실험에서 아토피 피부염을 개선시키는 효과가 있음을 알았고 임상에서 아토피 환자를 대상으로 아토피 피부염 개선제제로서의 가능성을 확인할 수 있었다. 이상의 결과를 토대로 보다 광범위한 임상연구를 시도하고자 한다.